I hope you don't use APFS…

APFS can handle FOO and foo just fine, and I think only on macOS do you have to ask nicely that you'd like to have them not conflict, iOS and watchOS already do that by default. I have observed no problems with running a fully case sensitive macOS install.

Interesting! I seem to recall that not all to long ago a lot of things would completely break if you tried to use a case-sensitive filesystem.

I think Adobe or other entrenched bloatware might still break, but I had zero problems with it so far and I use a reasonable range of applications.

Nope. NetBSD...