Sophisticated customers hacking the instruction sets of their machines goes back pretty much to the beginning. The earliest I personally know of is Prof Jack Dennis hacking MIT's PDP-1 to support timesharing, sometime in 1961. Commercial machines like the Burroughs B1700 had a WCS that was designed so various compiled languages could be optimized - e.g. a FORTRAN instruction set, a COBOL instruction set, etc https://en.wikipedia.org/wiki/Burroughs_B1700 It was also in the IBM360s because they had to emulate the IBM1401 software (although I don't know if the capability was open to users to modify).
Today of course you have the various optional features of the RISC-V ecosystem --- easy to load up on an FPGA.
Perhaps we should remember that we are in the very very early days of Computers, and we should expect continued modification / experimentation.
